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Two 10-year-old girls had classic,focal hyperintensities in the internal capsules and globus pallidus regions,which have been associated with NF-1. The third patient,a neonate,had diffuse hypertensity of the supratentorial and infratentorial white matter on T2-weighted MR images.Findings at histopathologic examination revealed spongiotic change in the tissue sections that correspond to the high-signal-intensity foci demonstrated on T2-weighted images.Hyperintense foci seen on T2-weighted MR images appear to correspond to pathologic findings of areas of vacuolar or spongiotic change.The resultant fluid-filled vacuoles explain the occurrence of high signal intensity demonstrated on T2-weighted images. |
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basal ganglia,lesion of
globus pallidus,lesion of
globus pallidus,lesion of,bilateral
MRI
MRI,abnormal
MRI,high signal foci on
neurofibromatosis 1
neuropathology
neuropathology,brain
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